{"created":"2023-05-15T15:14:24.915535+00:00","id":53,"links":{},"metadata":{"_buckets":{"deposit":"ca968c8e-2c44-4fe0-9582-227f0b2ee3c8"},"_deposit":{"created_by":10,"id":"53","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"53"},"status":"published"},"_oai":{"id":"oai:rchokkaido-cn.repo.nii.ac.jp:00000053","sets":["8:16"]},"author_link":["201","180"],"control_number":"53","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"25","bibliographicPageStart":"1","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"日本赤十字北海道看護大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Japanese Red Cross Hokkaido College of Nursing","bibliographic_titleLang":"en"}]}]},"item_10002_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"この総説では、発達中の副腎髄質細胞のコリナージックレセプター関連分泌がいつ頃発現し、いつ頃機能的になり、そしていつ頃形態変化を起こすのかについて述べている。交感神経―副腎髄質前駆細胞は神経堤由来細胞の中でおもな系統を構成している。これらの細胞から交感神経細胞と内分泌の副腎髄質細胞が分化している。副腎髄質細胞は交感神経と相同であり、節前神経性のコリナージック神経線維によって神経支配されている。発達中の副腎髄質細胞は、最初にノルアドレナリンのみを細胞内で合成し、その後にノルアドレナリン（ＮＡ）とアドレナリン（Ａ）を同一細胞内で合成し（混合細胞）、最終的にノルアドレナリンはＮＡ細胞、アドレナリンはＡ細胞でそれぞれ合成していた。コリナージック指標蛋白（アセチルコリンエステラーゼ、コリンアセチル転移酵素、アセチルコリン小胞輸送蛋白）の反応神経線維は胎児期中の副腎髄質では無いかまたは極めて少なかったが、生後発達中に急激に増加した。発達中の副腎内のコリナージック神経は、最初は全く顆粒がないか極めて少数の無芯小胞を含んでいた、その後は多くの無芯小胞と少数の有芯小胞を含んでいた。アセチルコリン刺激では、副腎髄質細胞はニコチニックとムスカリニックレセプターを介する開口放出によってカテコールアミンの分泌が起こった。発達中の副腎髄質細胞のコリナージック刺激では、最初は無反応で、その後まずニコチニックレセプター関連分泌が出現し、その後にムスカリニックレセプター関連とニコチニック関連分泌、あるいはニコチニックレセプター関連分泌のみが起こった。これらのことを考え合わせると、発達中の副腎髄質細胞や副腎内のコリナージック神経の形態変化はコリナージック関連の分泌メカニズムの発現に関係し、さらに発達中の副腎髄質ではニコチニックレセプター関連分泌を介したメカニズムが、ムスカリニックレセプター関連分泌に先んじて出現していた。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本赤十字北海道看護大学","subitem_publisher_language":"ja"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"40020461783","subitem_relation_type_select":"NAID"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11558248","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-1745","subitem_source_identifier_type":"PISSN"}]},"item_10002_textarea_1":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"This article reviews when the cholinergic receptor-mediated secretion mechanism of developing adrenal chromaffin cells is expressed and becomes functional, morphological changes.  Sympatho-adrenal progenitor cells constituted a major lineage among neural crest derivatives.  These give rise to sympathetic neurons and endocrine chromaffin cells.  Adrenal chromaffin cells are homologous to sympathetic ganglia, which are innervated by preganglionic cholinergic nerves.  Developing adrenal chromaffin cells synthesized, first noradrenaline alone in the cells, subsequently noradrenaline (NA) and adrenaline (A) in single cell (mixed cell), finally NA in NA cells and A in A cells, respectively.  Cholinergic marker proteins (acetylcholinesterase, choline acetyltransferase and vesicular acetylcholine transporter) reactive nerve fibers were no or very few in the adrenal medulla during embryonic development, and increased dramatically during early postnatal development.  Developing intra-adrenal cholinergic nerve fibers contained, first no or very few clear vesicles, subsequently numerous clear vesicles and a few dense-cored vesicles.  Cholinergic stimulation induced a secretion of catecholamines from chromaffin cells by exocytosis via muscarinic- and nicotinic-receptor.  Developing adrenal chromaffin cells after cholinergic stimulation showed no response, subsequently appeared first nicotinic-receptor mediated secretion and then, muscarinic receptor- and nicotinic receptor-mediated secretion or nicotinic receptor-mediated alone secretion.  Taken together, morphological changes of the developing chromaffin cells and the intra-adrenal cholinergic nerve fibers were related to the expression of a cholinergic receptor-mediated secretion mechanism and that this mechanism via a nicotinic receptor-mediated secretion preceded the muscarinic receptor-mediated one during development."}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{}]}],"creatorNames":[{"creatorName":"大森, 行雄","creatorNameLang":"ja"},{"creatorName":"オオモリ, ユキオ","creatorNameLang":"ja-Kana"},{"creatorName":"Oomori, Yukio","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{}]}],"creatorNames":[{"creatorName":"村林, 宏","creatorNameLang":"ja"},{"creatorName":"ムラバヤシ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Murabayashi, Hiroshi","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-06"}],"displaytype":"detail","filename":"013_P001.pdf","filesize":[{"value":"15.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Cholinergic Receptor-Mediated Secretion Mechanism in Adrenal Chromaffin Cells during Development","url":"https://rchokkaido-cn.repo.nii.ac.jp/record/53/files/013_P001.pdf"},"version_id":"536b252f-6827-4e43-b57e-3b95370b332e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cholinergic innervation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cholinergic receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adrenal chromaffin cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"development","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"secretion","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"[総説]発達過程における副腎髄質細胞のコリナージック受容体関連分泌機構について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[総説]発達過程における副腎髄質細胞のコリナージック受容体関連分泌機構について","subitem_title_language":"ja"},{"subitem_title":"[Review Article]Cholinergic Receptor-Mediated Secretion Mechanism in Adrenal Chromaffin Cells during Development","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"10","path":["16"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-09-06"},"publish_date":"2017-09-06","publish_status":"0","recid":"53","relation_version_is_last":true,"title":["[総説]発達過程における副腎髄質細胞のコリナージック受容体関連分泌機構について"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-07-13T01:22:06.774169+00:00"}